| Season | Date | Home Team | Score | Away Team | Pts Diff |
|---|---|---|---|---|---|
| 26 | 14-03-2026 | Coventry | 1 - 2 | Southampton | 3 |
| 26 | 11-03-2026 | West Brom | 1 - 1 | Southampton | -2 |
| 26 | 28-02-2026 | Sheffield Weds | 1 - 3 | Southampton | 0 |
| 26 | 24-02-2026 | Southampton | 5 - 0 | QPR | 3 |
| 26 | 21-02-2026 | Southampton | 1 - 1 | Charlton | -2 |
| 26 | 10-02-2026 | Leicester | 3 - 4 | Southampton | 3 |
| 26 | 07-02-2026 | Southampton | 1 - 0 | Watford | 2 |
| 26 | 31-01-2026 | Stoke | 0 - 2 | Southampton | 3 |
| 26 | 25-01-2026 | Portsmouth | 1 - 1 | Southampton | -2 |
| 26 | 21-01-2026 | Southampton | 1 - 0 | Sheffield United | 0 |
| 26 | 17-01-2026 | Southampton | 1 - 2 | Hull | 0 |
| 26 | 04-01-2026 | Middlesbrough | 4 - 0 | Southampton | -3 |
| 26 | 01-01-2026 | Southampton | 0 - 0 | Millwall | -2 |
| 26 | 29-12-2025 | Birmingham | 1 - 1 | Southampton | -2 |
| 26 | 26-12-2025 | Oxford United | 2 - 1 | Southampton | 0 |
| 26 | 20-12-2025 | Southampton | 1 - 1 | Coventry | 0 |
| 26 | 13-12-2025 | Norwich | 2 - 1 | Southampton | -1 |
| 26 | 09-12-2025 | Southampton | 3 - 2 | West Brom | 2 |
| 26 | 06-12-2025 | Southampton | 3 - 1 | Birmingham | 0 |
| 26 | 29-11-2025 | Millwall | 3 - 2 | Southampton | -1 |
| 26 | 25-11-2025 | Southampton | 3 - 0 | Leicester | 2 |
| 26 | 22-11-2025 | Charlton | 1 - 5 | Southampton | 0 |
| 26 | 08-11-2025 | Southampton | 3 - 1 | Sheffield Weds | 0 |
| 26 | 05-11-2025 | QPR | 1 - 2 | Southampton | 2 |
| 26 | 01-11-2025 | Southampton | 0 - 2 | Preston | -1 |
| 26 | 25-10-2025 | Blackburn | 2 - 1 | Southampton | -1 |
| 26 | 21-10-2025 | Bristol City | 3 - 1 | Southampton | 0 |
| 26 | 18-10-2025 | Southampton | 0 - 0 | Swansea | 1 |
| 26 | 04-10-2025 | Derby | 1 - 1 | Southampton | -2 |
| 26 | 30-09-2025 | Sheffield United | 1 - 2 | Southampton | 3 |
| 26 | 27-09-2025 | Southampton | 1 - 1 | Middlesbrough | -2 |
| 26 | 20-09-2025 | Hull | 3 - 1 | Southampton | -3 |
| 26 | 14-09-2025 | Southampton | 0 - 0 | Portsmouth | -2 |
| 26 | 30-08-2025 | Watford | 2 - 2 | Southampton | 1 |
| 26 | 23-08-2025 | Southampton | 1 - 2 | Stoke | -3 |
| 26 | 17-08-2025 | Ipswich | 1 - 1 | Southampton | 0 |
| 26 | 09-08-2025 | Southampton | 2 - 1 | Wrexham | 2 |
| 25 | 21-04-2025 | Southampton | 0 - 1 | Blackburn | 0 |
| 25 | 21-12-2024 | Southampton | 2 - 1 | Norwich | 0 |
| 25 | 14-12-2024 | Swansea | 2 - 3 | Southampton | 0 |
| 25 | 10-12-2024 | Southampton | 1 - 1 | Bristol City | 0 |
| 25 | 06-11-2024 | Preston | 0 - 0 | Southampton | 0 |
| 25 | 26-10-2024 | Southampton | 2 - 0 | Oxford United | 0 |
| 25 | 01-10-2024 | Southampton | 2 - 0 | Derby | 0 |
| 25 | 14-09-2024 | Wrexham | 3 - 2 | Southampton | 0 |
| 25 | 24-08-2024 | Southampton | 1 - 0 | Ipswich | 0 |