| Season | Date | Home Team | Score | Away Team | Pts Diff |
|---|---|---|---|---|---|
| 26 | 05-11-2025 | QPR | 0 - 0 | Southampton | 0 |
| 26 | 01-11-2025 | Southampton | 0 - 2 | Preston | -1 |
| 26 | 25-10-2025 | Blackburn | 2 - 1 | Southampton | -1 |
| 26 | 21-10-2025 | Bristol City | 3 - 1 | Southampton | 0 |
| 26 | 18-10-2025 | Southampton | 0 - 0 | Swansea | 1 |
| 26 | 04-10-2025 | Derby | 1 - 1 | Southampton | -2 |
| 26 | 30-09-2025 | Sheffield United | 1 - 2 | Southampton | 3 |
| 26 | 27-09-2025 | Southampton | 1 - 1 | Middlesbrough | -2 |
| 26 | 20-09-2025 | Hull | 3 - 1 | Southampton | -3 |
| 26 | 14-09-2025 | Southampton | 0 - 0 | Portsmouth | -2 |
| 26 | 30-08-2025 | Watford | 2 - 2 | Southampton | 1 |
| 26 | 23-08-2025 | Southampton | 1 - 2 | Stoke | -3 |
| 26 | 17-08-2025 | Ipswich | 1 - 1 | Southampton | 0 |
| 26 | 09-08-2025 | Southampton | 2 - 1 | Wrexham | 2 |
| 25 | 03-05-2025 | Southampton | 0 - 1 | QPR | 0 |
| 25 | 26-04-2025 | Oxford United | 2 - 0 | Southampton | 0 |
| 25 | 21-04-2025 | Southampton | 0 - 1 | Blackburn | 0 |
| 25 | 08-04-2025 | Norwich | 0 - 0 | Southampton | 0 |
| 25 | 05-04-2025 | West Brom | 0 - 1 | Southampton | 0 |
| 25 | 29-03-2025 | Southampton | 1 - 0 | Millwall | 0 |
| 25 | 15-03-2025 | Coventry | 3 - 0 | Southampton | 0 |
| 25 | 08-03-2025 | Southampton | 2 - 1 | Charlton | 0 |
| 25 | 28-02-2025 | Sheffield Weds | 1 - 2 | Southampton | 0 |
| 25 | 22-02-2025 | Southampton | 0 - 1 | Hull | 0 |
| 25 | 17-02-2025 | Leicester | 2 - 1 | Southampton | 0 |
| 25 | 12-02-2025 | Southampton | 2 - 0 | Birmingham | 0 |
| 25 | 08-02-2025 | Southampton | 2 - 2 | Watford | 0 |
| 25 | 03-02-2025 | Middlesbrough | 2 - 3 | Southampton | 0 |
| 25 | 01-01-2025 | Southampton | 2 - 1 | Sheffield United | 0 |
| 25 | 29-12-2024 | Stoke | 1 - 0 | Southampton | 0 |
| 25 | 21-12-2024 | Southampton | 2 - 1 | Norwich | 0 |
| 25 | 14-12-2024 | Swansea | 2 - 3 | Southampton | 0 |
| 25 | 10-12-2024 | Southampton | 1 - 1 | Bristol City | 0 |
| 25 | 26-11-2024 | Southampton | 0 - 0 | West Brom | 0 |
| 25 | 23-11-2024 | Millwall | 1 - 1 | Southampton | 0 |
| 25 | 09-11-2024 | Southampton | 2 - 2 | Coventry | 0 |
| 25 | 06-11-2024 | Preston | 0 - 0 | Southampton | 0 |
| 25 | 26-10-2024 | Southampton | 2 - 0 | Oxford United | 0 |
| 25 | 23-10-2024 | Birmingham | 1 - 2 | Southampton | 0 |
| 25 | 04-10-2024 | Southampton | 2 - 2 | Leicester | 0 |
| 25 | 01-10-2024 | Southampton | 2 - 0 | Derby | 0 |
| 25 | 14-09-2024 | Wrexham | 3 - 2 | Southampton | 0 |
| 25 | 31-08-2024 | Portsmouth | 1 - 3 | Southampton | 0 |
| 25 | 24-08-2024 | Southampton | 1 - 0 | Ipswich | 0 |
| 25 | 18-08-2024 | Southampton | 4 - 0 | Sheffield Weds | 0 |
| 25 | 10-08-2024 | Charlton | 0 - 2 | Southampton | 0 |