| League | Date | Home Team | Score | Away Team |
|---|---|---|---|---|
| PL | 22-05-2022 | Burnley | 1 - 2 | Newcastle |
| PL | 16-05-2022 | Newcastle | 2 - 0 | Arsenal |
| PL | 08-05-2022 | Man City | 5 - 0 | Newcastle |
| PL | 30-04-2022 | Newcastle | 0 - 1 | Liverpool |
| PL | 23-04-2022 | Norwich | 0 - 3 | Newcastle |
| PL | 20-04-2022 | Newcastle | 1 - 0 | Crystal Palace |
| PL | 17-04-2022 | Newcastle | 2 - 1 | Leicester |
| PL | 08-04-2022 | Newcastle | 1 - 0 | Wolves |
| PL | 03-04-2022 | Tottenham | 5 - 1 | Newcastle |
| PL | 17-03-2022 | Everton | 1 - 0 | Newcastle |
| PL | 13-03-2022 | Chelsea | 1 - 0 | Newcastle |
| PL | 10-03-2022 | Southampton | 1 - 2 | Newcastle |
| PL | 05-03-2022 | Newcastle | 2 - 1 | Brighton |
| PL | 26-02-2022 | Brentford | 0 - 2 | Newcastle |
| PL | 19-02-2022 | West Ham | 1 - 1 | Newcastle |
| PL | 13-02-2022 | Newcastle | 1 - 0 | Aston Villa |
| PL | 08-02-2022 | Newcastle | 3 - 1 | Everton |
| PL | 22-01-2022 | Leeds | 0 - 1 | Newcastle |
| PL | 15-01-2022 | Newcastle | 1 - 1 | Watford |
| PL | 27-12-2021 | Newcastle | 1 - 1 | Man United |
| PL | 19-12-2021 | Newcastle | 0 - 4 | Man City |
| PL | 16-12-2021 | Liverpool | 3 - 1 | Newcastle |
| PL | 12-12-2021 | Leicester | 4 - 0 | Newcastle |
| PL | 04-12-2021 | Newcastle | 1 - 0 | Burnley |
| PL | 30-11-2021 | Newcastle | 1 - 1 | Norwich |
| PL | 27-11-2021 | Arsenal | 2 - 0 | Newcastle |
| PL | 20-11-2021 | Newcastle | 3 - 3 | Brentford |
| PL | 06-11-2021 | Brighton | 1 - 1 | Newcastle |
| PL | 30-10-2021 | Newcastle | 0 - 3 | Chelsea |
| PL | 23-10-2021 | Crystal Palace | 1 - 1 | Newcastle |
| PL | 17-10-2021 | Newcastle | 2 - 3 | Tottenham |
| PL | 02-10-2021 | Wolves | 2 - 1 | Newcastle |
| PL | 25-09-2021 | Watford | 1 - 1 | Newcastle |
| PL | 17-09-2021 | Newcastle | 1 - 1 | Leeds |
| PL | 11-09-2021 | Man United | 4 - 1 | Newcastle |
| PL | 28-08-2021 | Newcastle | 2 - 2 | Southampton |
| PL | 21-08-2021 | Aston Villa | 2 - 0 | Newcastle |
| PL | 15-08-2021 | Newcastle | 2 - 4 | West Ham |