| League | Date | Home Team | Score | Away Team |
|---|---|---|---|---|
| CH | 08-05-2021 | QPR | 3 - 1 | Luton |
| CH | 04-05-2021 | Luton | 0 - 0 | Rotherham |
| CH | 01-05-2021 | Luton | 1 - 1 | Middlesbrough |
| CH | 25-04-2021 | Bristol City | 2 - 3 | Luton |
| CH | 21-04-2021 | Luton | 0 - 0 | Reading |
| CH | 17-04-2021 | Luton | 1 - 0 | Watford |
| CH | 10-04-2021 | Wycombe | 1 - 3 | Luton |
| CH | 05-04-2021 | Luton | 1 - 2 | Barnsley |
| CH | 02-04-2021 | Derby | 2 - 0 | Luton |
| CH | 20-03-2021 | Preston | 0 - 1 | Luton |
| CH | 16-03-2021 | Luton | 2 - 0 | Coventry |
| CH | 13-03-2021 | Luton | 0 - 1 | Swansea |
| CH | 06-03-2021 | Norwich | 3 - 0 | Luton |
| CH | 02-03-2021 | Notts Forest | 0 - 1 | Luton |
| CH | 27-02-2021 | Luton | 3 - 2 | Sheffield Weds |
| CH | 23-02-2021 | Luton | 1 - 1 | Millwall |
| CH | 20-02-2021 | Stoke | 3 - 0 | Luton |
| CH | 16-02-2021 | Luton | 0 - 2 | Cardiff |
| CH | 13-02-2021 | Birmingham | 0 - 1 | Luton |
| CH | 06-02-2021 | Luton | 1 - 1 | Huddersfield |
| CH | 30-01-2021 | Blackburn | 1 - 0 | Luton |
| CH | 20-01-2021 | Brentford | 1 - 0 | Luton |
| CH | 16-01-2021 | Bournemouth | 0 - 1 | Luton |
| CH | 12-01-2021 | Luton | 0 - 2 | QPR |
| CH | 29-12-2020 | Luton | 2 - 1 | Bristol City |
| CH | 26-12-2020 | Reading | 2 - 1 | Luton |
| CH | 19-12-2020 | Luton | 0 - 0 | Bournemouth |
| CH | 16-12-2020 | Middlesbrough | 1 - 0 | Luton |
| CH | 12-12-2020 | Luton | 3 - 0 | Preston |
| CH | 08-12-2020 | Coventry | 0 - 0 | Luton |
| CH | 05-12-2020 | Swansea | 2 - 0 | Luton |
| CH | 02-12-2020 | Luton | 3 - 1 | Norwich |
| CH | 28-11-2020 | Cardiff | 4 - 0 | Luton |
| CH | 24-11-2020 | Luton | 1 - 1 | Birmingham |
| CH | 21-11-2020 | Luton | 1 - 1 | Blackburn |
| CH | 07-11-2020 | Huddersfield | 1 - 1 | Luton |
| CH | 04-11-2020 | Rotherham | 0 - 1 | Luton |
| CH | 31-10-2020 | Luton | 0 - 3 | Brentford |
| CH | 28-10-2020 | Luton | 1 - 1 | Notts Forest |
| CH | 24-10-2020 | Sheffield Weds | 0 - 1 | Luton |
| CH | 20-10-2020 | Millwall | 2 - 0 | Luton |
| CH | 17-10-2020 | Luton | 0 - 2 | Stoke |
| CH | 03-10-2020 | Luton | 2 - 0 | Wycombe |
| CH | 26-09-2020 | Watford | 1 - 0 | Luton |
| CH | 19-09-2020 | Luton | 2 - 1 | Derby |
| CH | 12-09-2020 | Barnsley | 0 - 1 | Luton |