| League | Date | Home Team | Score | Away Team |
|---|---|---|---|---|
| CH | 07-05-2022 | Peterborough | 5 - 0 | Blackpool |
| CH | 30-04-2022 | Blackpool | 0 - 2 | Derby |
| CH | 26-04-2022 | Barnsley | 0 - 2 | Blackpool |
| CH | 23-04-2022 | Luton | 1 - 1 | Blackpool |
| CH | 18-04-2022 | Blackpool | 6 - 1 | Birmingham |
| CH | 15-04-2022 | West Brom | 2 - 1 | Blackpool |
| CH | 09-04-2022 | Blackburn | 1 - 1 | Blackpool |
| CH | 05-04-2022 | Preston | 1 - 0 | Blackpool |
| CH | 02-04-2022 | Blackpool | 1 - 4 | Notts Forest |
| CH | 16-03-2022 | Blackpool | 0 - 0 | Sheffield United |
| CH | 12-03-2022 | Blackpool | 1 - 0 | Swansea |
| CH | 05-03-2022 | Stoke | 0 - 1 | Blackpool |
| CH | 26-02-2022 | Blackpool | 4 - 1 | Reading |
| CH | 23-02-2022 | QPR | 2 - 1 | Blackpool |
| CH | 19-02-2022 | Cardiff | 1 - 1 | Blackpool |
| CH | 12-02-2022 | Blackpool | 1 - 2 | Bournemouth |
| CH | 08-02-2022 | Coventry | 1 - 1 | Blackpool |
| CH | 05-02-2022 | Blackpool | 3 - 1 | Bristol City |
| CH | 29-01-2022 | Fulham | 1 - 1 | Blackpool |
| CH | 22-01-2022 | Blackpool | 1 - 0 | Millwall |
| CH | 01-01-2022 | Blackpool | 1 - 0 | Hull |
| CH | 29-12-2021 | Blackpool | 1 - 2 | Middlesbrough |
| CH | 26-12-2021 | Huddersfield | 3 - 2 | Blackpool |
| CH | 18-12-2021 | Blackpool | 3 - 1 | Peterborough |
| CH | 11-12-2021 | Derby | 1 - 0 | Blackpool |
| CH | 04-12-2021 | Blackpool | 0 - 3 | Luton |
| CH | 27-11-2021 | Birmingham | 1 - 0 | Blackpool |
| CH | 23-11-2021 | Blackpool | 0 - 0 | West Brom |
| CH | 20-11-2021 | Swansea | 1 - 1 | Blackpool |
| CH | 06-11-2021 | Blackpool | 1 - 1 | QPR |
| CH | 03-11-2021 | Blackpool | 0 - 1 | Stoke |
| CH | 30-10-2021 | Sheffield United | 0 - 1 | Blackpool |
| CH | 23-10-2021 | Blackpool | 2 - 0 | Preston |
| CH | 20-10-2021 | Reading | 2 - 3 | Blackpool |
| CH | 16-10-2021 | Notts Forest | 2 - 1 | Blackpool |
| CH | 02-10-2021 | Blackpool | 2 - 1 | Blackburn |
| CH | 28-09-2021 | Hull | 1 - 1 | Blackpool |
| CH | 25-09-2021 | Blackpool | 1 - 0 | Barnsley |
| CH | 18-09-2021 | Middlesbrough | 1 - 2 | Blackpool |
| CH | 14-09-2021 | Blackpool | 0 - 3 | Huddersfield |
| CH | 11-09-2021 | Blackpool | 1 - 0 | Fulham |
| CH | 28-08-2021 | Millwall | 2 - 1 | Blackpool |
| CH | 21-08-2021 | Bournemouth | 2 - 2 | Blackpool |
| CH | 17-08-2021 | Blackpool | 0 - 1 | Coventry |
| CH | 14-08-2021 | Blackpool | 0 - 2 | Cardiff |
| CH | 07-08-2021 | Bristol City | 1 - 1 | Blackpool |